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KMID : 0370019960100000173
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Chung-Ang Journal of Pharmacal Sciences
1996 Volume.10 No. 0 p.173 ~ p.182
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Sustained Release Suspension Formulations of Famotidine by Cationic Ion Exchange Resin Comlexation
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Abstract
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Famotidine is poorly water-soluble and relatively susceptible to acid-catalyzed hydrolysis. Although famotidine undergoes minimal first-pass metabolism, its oral bioavailability has been reported to be relatively low. Ion exchange resin complexes of famotidine have been prepared by the reaction of famotidine solution with activated ion exchange resins. Drug release characteristics from the resin complexes were evaluated by the batch elution method. Famotidine release was dependent on the type of ion exchange resins. Strongly acidic resins revealed some advantages over weakly acidic resins for overcoming instability of famotidine in gastric juice. The stability of famotidine-resin complexes upon storage in distilled water and aqueous solutions containing flavors and sweeteners such as peppermint essence, lemon essence, stevioside, and sorbitol was evaluated for further development of a sustained-release suspension formulation. The cumulative famotidine release from strongly acidic resin complexes was about 10% after 60 days storage n water, but it was less than 2% after 60 days strorage in the above aqueous solution, due to the ion-masking effect of these excipients.
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